「Using hands with talent」for「stiff protrusion」and「front view of genitals」or「using hands to fend off a rabid animal」or「talented and demonically wicked」all suggest the given external definitions of STRIVE and ENDEAVOR, yet connote a somewhat negative sense as in a STRENUOUS EFFORT. The STRAIN and EFFORT associated with becoming clean again after a sexually transmitted infection, if that was possible, to STRIVE and ENDEAVOR to remain healthy by heeding the red flag warnings of one's buddies.
　「Using hands to accomplish a task with unhealthy influences that cause disease」may refer to manually self-stimulating on a regular basis, similar as do horses, until ejaculation occurs using masturbation to prevent prostate cancer:「Two relatively large studies of this question, reported in 2003 and 2004, yielded good news for sexually active men: high ejaculation frequency seemed to protect against prostate cancer.
　As part of Harvard's Health Professionals Follow-up Study, 29,342 men between the ages of 46 and 81 reported their average number of ejaculations per month in young adulthood (ages 20–29), in mid-life (ages 40–49), and in the most recent year. Ejaculations included sexual intercourse, nocturnal emissions, and masturbation. Study participants also provided comprehensive health and lifestyle data every two years from 1992 to 2000. The scientists found that men who ejaculated 21 or more times a month enjoyed a 33% lower risk of prostate cancer compared with men who reported four to seven ejaculations a month throughout their lifetimes.
　An Australian study of 2,338 men came to a similar conclusion. In all, men who averaged 4.6 to seven ejaculations a week were 36% less likely to be diagnosed with prostate cancer before the age of 70 than men who ejaculated less than 2.3 times a week on average. The study found no connection between prostate cancer and the number of sex partners. (An earlier study, however, found that men who had sex with 30 or more women were two to three times more likely to develop prostate cancer than men with only one partner.)」
　　[　https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387502/ 2020-12-30　]　…but not all the pundits agree…we say,「it can't hurt to try」
　　[　https://www.fatherly.com/health/more-sex-ejaculation-masturbation-lower-prostate-cancer-risk　]　
　　[　https://www.mayoclinic.org/diseases-conditions/prostate-cancer/expert-answers/prostate-cancer/faq-20057800　]　
　Lastly,「using talented hands with stiff protrusion and front view of genitals」or「hand use with unhealthy influences that cause disease」may refer to BOUGIE REAMING the urethra of a gonorrhea patient. It has been speculated that boogie woogie (or bougie wougie, or booga rooga, or boogie oogie, and so on) blues music that may have originated in the piney woods of East Texas turpentine camps during the 1860-70s, which at first was characterised by a low, slow, steadily repeating bass rhythm akin to both a steam locomotive pistons scraping (to turn the wheels with a reciprocating rod in horizontal motion powered by the steam engine, not unlike the motions of a bougie) and to slow coitus, was a musical manifestation of the sadness and pain associated with penile reaming using a bougie, and the resulting oozing with a woozy feeling that accompanied this procedure (becoming "woozy from the bougie" morphed into "boogie-woogie" eventually with the "gie" sound mispronounced as a hard-sounding "g"). Brothels were formerly called 'boogie houses' for reasons other than as a place where sexual intercourse occurred, but also as a place where one contracted gonorrhea, 'the clap' with is slowly rhythmic dripping beats that caused the need for repeated bougie-boogie reamings and oozings…what other commentators miss is the fact that brothel houses of prostitution were called 'bougie houses' long prior to the advent of the music…and that the music was named after whores passing to everyone gonorrhea, not vice versa. This musical genre originated along the「Texas & Pacific Railroad, known lovingly as the 'Tits Ass Pussy Railroad' because of the large numbers of brothels near T&P tracks, and because prostitutes ('Railroad Ladies') often hitched rides on the T&P」　[　https://nonjohn.com/History%20of%20Boogie%20Woogie.htm 2019-06-16　]　 obviously forgetting that the bougie house was where clap was contracted and the need for a bougie-boogie reaming became evident. See the lyrics to the original boogie-woogie tunes of the 1870s for further details.

Modern definitions (that generally disregard history) …excluding politically incorrect concepts and other meanings deemed offensive today; may list only pigeonholed definitions, euphemisms, or meaningless mnemonics)
Unihan extended: strive, endeavor
EDRDG: strive; endeavor